Dendritic cell subsets: the ultimate T cell differentiation decision makers?

Dendritic cell subsets: the ultimate T cell differentiation decision makers?

It is not known whether subsets of dendritic cells provide diVerent cytokine microenvironments that determine the diVerentiation of either type-1 T helper (TH1) or TH2 cells. Human monocyte (pDC1)-derived dendritic cells (DC1) were found to induce TH1 diVerentiation, whereas dendritic cells (DC2) derived from CD4+CD3−CD11c− plasmacytoid cells (pDC2) induced TH2 diVerentiation by use of a mechan...

Comparison of Several Maturation Inducing Factors in Dendritic Cell Differentiation

Background: Dendritic cells (DCs) are professional antigen presenting cells that have an important role in the initiation of immune response. The use of maturation factors in dendritic cell differentiation provides a promising approach in immunotherapy. Objective: In this study, we compared tumor necrosis factor-α, polyribocytidylic acid, lipopolysacharide and CpG oligonucleotides in inducing d...

Human dendritic cell subsets

Dendritic cells are highly adapted to their role of presenting antigen and directing immune responses. Developmental studies indicate that DCs originate independently from monocytes and tissue macrophages. Emerging evidence also suggests that distinct subsets of DCs have intrinsic differences that lead to functional specialisation in the generation of immunity. Comparative studies are now allow...

Ultimate Effector Differentiation Helper T Cell Program but Cannot Complete Antigen Presentation Initiates the Follicular Cutting Edge: Dendritic Cell-Restricted

Transcriptional control in the Th1/Th2 decision T-cell subsets:

Naive (precursor) CD4+ helper T cells recognize specific major histocompatibility complex (MHC)–peptide combinations on antigen-presenting cells (APCs) via interactions with the T-cell receptor (TCR), thereby providing the first signal required for activation. The second, costimulatory signal, is provided by accessory molecules expressed on APCs, such as the widely studied B7 family of proteins...